Industry (NYC)

Anyone else notice how nasty the guys are at industry towards non male patrons? I've always had a good time at Industry but once it gets past 12 and the drinks are hitting people, the other patrons seem to get really nasty towards my friend (female). The situations get so bad I sometimes have to step in to diffuse them. I love the bar but the guys get really territorial. Anyone else have bars in their respective hometowns this happens too?