Gays I need your help!

Ok I need help and I don't know what to do. My friend is gay. He's so comfortable with his sexuality. But he's 6'4 and weighs pounds. He acts happy around me but I know he's actually really sad. He's never been with anyone and hasn't even had his first kiss. He can't exercise due to a disease he has. I think he's giving up on everything. What should I do?